Oxygen diffusion and consumption of aortic valve cusps
نویسندگان
چکیده
منابع مشابه
Oxygen diffusion and consumption of aortic valve cusps.
To maintain tissue oxygenation, normal aortic valves contain a vascular bed where tissue thickness is greatest. Avascular "living" tissue-engineered heart valves have been proposed, yet little information exists regarding the magnitude of valve tissue metabolic activity or oxygen requirements. We therefore set out to measure the oxygen diffusivity (DO(2)) and oxygen consumption (VO(2)) of seven...
متن کاملElevated cyclic stretch alters matrix remodeling in aortic valve cusps: implications for degenerative aortic valve disease.
Matrix metalloproteinases (MMPs) and cathepsins are proteolytic enzymes that are upregulated in diseased aortic valve cusps. The objective of this study was to investigate whether elevated cyclic stretch causes an increased expression and activity of these proteolytic enzymes in the valve cusp. Circumferentially oriented fresh porcine aortic valve cusp sections were stretched to 10% (physiologi...
متن کاملProgression of aortic valve stenosis: TGF-beta1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis.
BACKGROUND Aortic valve stenosis characteristically progresses due to cuspal calcification, often necessitating valve replacement surgery. The present study investigated the hypothesis that TGF-beta1, a cytokine that causes calcification of vascular smooth muscle cells in culture, initiates apoptosis of valvular interstitial cells as a mechanistic event in cuspal calcification. METHODS Noncal...
متن کاملMyocardial Oxygen Consumption and Efficiency in Aortic Valve Stenosis Patients With and Without Heart Failure
BACKGROUND Myocardial oxygen consumption (MVO2) and its coupling to contractile work are fundamentals of cardiac function and may be involved causally in the transition from compensated left ventricular hypertrophy to failure. Nevertheless, these processes have not been studied previously in patients with aortic valve stenosis (AS). METHODS AND RESULTS Participants underwent 11C-acetate posit...
متن کاملObserved change in peak oxygen consumption after aortic valve replacement and its predictors
OBJECTIVE To assess the change in peak oxygen consumption (pVO2) and determine its outcome predictors after aortic valve replacement (AVR) for aortic stenosis (AS). METHODS Patients with AS and preserved left ventricular ejection fraction who were referred for single AVR had cardiopulmonary exercise testing prior to and 9 months post-AVR. Predictors of outcome for pVO2 were determined by mult...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Heart and Circulatory Physiology
سال: 2001
ISSN: 0363-6135,1522-1539
DOI: 10.1152/ajpheart.2001.281.6.h2604